Phosphine-catalyzed domino reaction: an efficient method for the synthesis of highly functionalized spirooxazolines.
نویسندگان
چکیده
A novel phosphine-catalyzed intermolecular [3 + 2] cycloaddition of ynones and N-substituted isatins was developed. In this reaction, substituted ynones, serving as a C(3) synthon, were successfully applied in intermolecular annulation reactions. A number of functionalized spirooxazolines were obtained in high yields and stereoselectivity.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 37 شماره
صفحات -
تاریخ انتشار 2012